The Ongoing Hopes and Challenges of Cancer Vaccines
نویسنده
چکیده
Cancer vaccines seem straightforward and elegant in theory, yet the effective application of the concept has been largely elusive. Numerous cancer vaccines have shown promise in early phases of development only to have difficulties meeting endpoints in Phase 3 clinical trials. Despite these shortcomings, established pharmaceutical companies have become increasingly interested in cancer immunotherapies; and currently, there are over 100 immunotherapy products in various stages of development. Of these, many are specific active immunotherapies (vaccines) that have already entered into clinical development, and several, as illustrated in Table 1, are currently in or have recently completed Phase 3 trials.
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